By I. Scharrer (auth.), Professor Dr. med. Inge Scharrer, Professor Dr. med. Wolfgang Schramm (eds.)
This ebook comprises the contribution to the thirty seventh Hemophilia Symposium, Hamburg 2006. the most issues are epidemiolgy, therapy of inhibitors in hemophiliacs, hemophilic arthropathy and synovitis, proper hemophilia therapy 2006, and pediatric hemostasiology. the amount is rounded off by means of various loose papers and posters on hemophilia, casuistics, and diagnostics.
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Additional info for 37th Hemophilia Symposium
Ilas, H. P. Schwarz, and B. M. Reipert Summary The development of neutralizing anti-FVIII antibodies (FVIII inhibitors) in about 25% of patients with severe hemophilia A is the most serious complication in the treatment of hemophilia A patients with FVIII products. Little information is available on the immunological mechanisms that regulate the development and maintenance of FVIII inhibitors in patients. Memory B cells are a central component of humoral immunity. They drive the rapid anamnestic antibody response that occurs after re-exposure to antigen and seem to be important for replenishing the pool of long-lived plasma cells to maintain long-term antibody levels in the absence of antigen.
7. Quintana M, del Amo J, Barrasa A, Perez-Hoyos S, Ferreros I, Hernandez F, Villar A, Jimenez V, Bolumar F: Progression of HIV infection and mortality by hepatitis C infection in patients with haemophilia over 20 years. Haemophilia. 2003 Sep;9(5):605–12 Ragni MV, Belle SH: Impact of human immunodeﬁciency virus infection on progression to end-stage liver disease in individuals with hemophilia and hepatitis C virus infection. J Infect Dis. 2001 Apr 1;183(7):1112-5. Epub 2001 Mar 01 Santagostino E, Colombo M, Rivi M, Rumi MG, Rocino A, Linari S, Mannucci PM; Study Group of the Association of Italian Hemophilia Centers: A 6-month versus a 12-month surveillance for hepatocellular carcinoma in 559 hemophiliacs infected with the hepatitis C virus.
HSA was used as negative control. The percentage of antigen-speciﬁc cells related to total IgG-producing cells as well as the limit of detection was calculated for each patient Detection of Factor VIII-Speciﬁc Memory B Cells in Patients with Hemophilia A and ... Discussion Memory B cells play an essential role in the maintenance of established antibody responses. Upon re-exposure to the same antigen, they are rapidly re-stimulated to proliferate and differentiate into antibody-producing plasma cells that secrete high-afﬁnity antibodies [3–6].
37th Hemophilia Symposium by I. Scharrer (auth.), Professor Dr. med. Inge Scharrer, Professor Dr. med. Wolfgang Schramm (eds.)