Download PDF by Georg Gübitz, Alexander Bauer, Guenther Bochmann, Andreas: Advances in Biochemical Engineering Biotechnology Metabolic

By Georg Gübitz, Alexander Bauer, Guenther Bochmann, Andreas Gronauer, Stefan Weiss

Michael Lebuhn, Stefan Weiß, Bernhard Munk, Georg M. Guebitz

Microbiology and Molecular Biology instruments for Biogas strategy research, prognosis and Control

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Anaerobic Fungi and their power for Biogas Production

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Hygiene and Sanitation in Biogas Plants

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Direct Interspecies Electron move in Anaerobic Digestion: A Review

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Influent Fractionation for Modeling non-stop Anaerobic Digestion Processes

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Fate of hint Metals in Anaerobic Digestion

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Extra resources for Advances in Biochemical Engineering Biotechnology Metabolic Engineering

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Biochem J 260: 339–343 90. Marsden AFA, Caffrey P, Aparicio JF, Loughran MS, Staunton J, Leadlay PF (1994) Stereospecific acyl transfers on the erythromycin-producing polyketide synthase. Science 263:378–380 91. Merson-Davies LA, Cundliffe E (1994) Analysis of five tylosin biosynthetic genes from the tylIBA region of the Streptomyces fradiae genome. Mol Microbiol 13:349–355 92. Wu K, Chung L, Revill WP, Katz L, Reeves CD (2000) The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

Marsden AFA, Caffrey P, Aparicio JF, Loughran MS, Staunton J, Leadlay PF (1994) Stereospecific acyl transfers on the erythromycin-producing polyketide synthase. Science 263:378–380 91. Merson-Davies LA, Cundliffe E (1994) Analysis of five tylosin biosynthetic genes from the tylIBA region of the Streptomyces fradiae genome. Mol Microbiol 13:349–355 92. Wu K, Chung L, Revill WP, Katz L, Reeves CD (2000) The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

1 Heterologous Expression of Polyketides Over the past few years, the expression of all or part of a polyketide pathway in a genetically friendly heterologous host is becoming an increasingly attractive alternative to performing strain and process improvement for polyketide production in the native producing organism. There are three key advantages of heterologous expression for the overproduction of a new polyketide metabolite. First, heterologous expression offers the advantage of PKS protein overexpression compared to native producing hosts, since well-developed promoter-regulator systems can be used.

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Advances in Biochemical Engineering Biotechnology Metabolic Engineering by Georg Gübitz, Alexander Bauer, Guenther Bochmann, Andreas Gronauer, Stefan Weiss


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