Advances in Structure and Activity Relationship of Coumarin by Santhosh Penta PDF

By Santhosh Penta

ISBN-10: 0128037970

ISBN-13: 9780128037973

ISBN-10: 012803873X

ISBN-13: 9780128038734

Advances in constitution and task courting of Coumarin Derivatives covers the structural habit of varied coumarin derivatives for numerous strength pharmaceutical purposes. in line with substitution designated for lively websites, the publication takes a rational procedure for designing new and particular effective medicinal drugs, optimizing current ones, and constructing novel reactions. This centred primer describes the chemical constitution and job of coumarin derivatives to discover the consequences of other substituents at particular positions, and their homes for powerful bioactivity.

  • Accessible and present insurance of coumarin derivatives from constitution to power applications
  • Application of SAR know-how to foretell bioactivity of the derivatives in response to its chemical structure
  • Information for researchers in medicinal chemistry, pharmaceutical sciences, and similar fields

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Additional info for Advances in Structure and Activity Relationship of Coumarin Derivatives

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6 Fused Ring at C3-C4 Position ...................................................... 7 Functional Group at C5 Position................................................ 8 Functional Group at C6 Position................................................ 9 Functional Group at C7 Position................................................ 10 Disubstituted Group at C6 and C7 position ........................... 11 Disubstituted Group at C7 and C8 position ........................... 12 Fused Ring at C7-C8 Position....................................................

29 Hepatitis C virus (HCV) is the main causative agent of hepatitis C, a transmittable disease mainly affecting the liver. Chronic infection can lead to damaging of the liver and ultimately to cirrhosis, which is commonly seen after many years of infection. 7 HCV infected liver. org/articles/computational-analysis-hcv-entry-inhibitorshepatitis-c-treatment-molecular-docking-approach 33 Antimicrobial Agents Methyl Group Benzimidazole-coumarin nucleus substituted with methyl group hybrids such as [59] and [60] exhibit significant anti-HCV activity.

43 The carbonic anhydrases (or carbonate dehydratases) constitute a group of enzymes. These are applicable as catalysts for rapid interconversion of carbon dioxide and water to bicarbonate and protons, and vice versa. In the absence of catalysts’ reversible reaction, that occurs relatively slowly. 3 Ribben Diagram of Carbonic Anhydrase. html. O O O 106a. 6-substituted 106b. 7-substituted 106c. 2 Amine Group The influence of complexes of the general formula PdL2 substituted with coumarin at the N atom was examined on two human leukemia cell lines, NALM-6 and HL-60.

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Advances in Structure and Activity Relationship of Coumarin Derivatives by Santhosh Penta


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