Samira Mubareka, Peter Palese (auth.), Rino Rappuoli,'s Influenza Vaccines for the Future PDF

By Samira Mubareka, Peter Palese (auth.), Rino Rappuoli, Giuseppe Del Giudice (eds.)

ISBN-10: 3034602782

ISBN-13: 9783034602785

ISBN-10: 3034602790

ISBN-13: 9783034602792

The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine foundation in 2009 demands new, fast and sustainable ideas for either seasonal and pandemic influenza viruses. over the past ten years, technology and know-how have made huge, immense development, and we're now capable of video display in actual time the genetics of viruses whereas they unfold globally, to make extra strong vaccines utilizing novel adjuvants, and to generate viruses within the laboratory utilizing opposite genetics. This quantity not just presents state of the art details at the biology of influenza viruses and on influenza vaccines, yet can be designed to be a source to stand the current H1N1 pandemic and to plot for long term worldwide and sustainable solutions.

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The innate immune system is the first line of host defense, and the influenza virus possesses the ability to interfere with this response. Type I interferons (IFN-a/b) are central to establishing an antiviral state in host cells. Interferon antagonism has been primarily attributed to the NS1 protein of influenza virus, which plays a multifunctional role in preventing the activation of IFN transcription factors (for review, see [140, 141]). The effect of avian influenza virus NS1 on IFN production has also been explored.

Consequently, in a 60-day period, there could be R(60/4) to R(60/2) infections. Overall, the use of time series of population-level data (hospitalizations, mortality) in large populations has provided a more complete picture of the transmissibility of influenza through space and time. One study correlated mortality peaks in US influenza seasons for the last 30 years with daily transportation data and found that epidemics spread across the country in an average of about 6 weeks and that transmission was correlated with adult work travel patterns [14].

Guinea pigs are highly susceptible to infection with an unadapted human H3N3 (A/Panama/2002/1999, or Pan99) influenza virus, with a 50% infectious dose of 5 PFU, and this virus grows to high titers in the upper respiratory tract and to moderate titers in the lungs. Transmission of Pan99 by direct contact and aerosol in this system is 100% (Fig. 6) [153]; however, transmission efficiency may vary among influenza virus subtypes [154]. Environmental factors such as temperature and relative humidity also appear to play a substantial role [155, 156].

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Influenza Vaccines for the Future by Samira Mubareka, Peter Palese (auth.), Rino Rappuoli, Giuseppe Del Giudice (eds.)


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